2-[bis(carboxymethyl)amino]acetic acid -Drug Synthesis Database

【结构式】

【分子编号】28806

【品名】2-[bis(carboxymethyl)amino]acetic acid

【CA登记号】139-13-9

【分子式】C₆H₉NO₆

【分子量】191.1406

【元素组成】C 37.7% H 4.75% N 7.33% O 50.22%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

The bromination of 2,4,6-trimethylaniline (I) with Br2 in aqueous HCl gives 3-bromo-2,4,6-trimethyl-aniline (II), which is then condensed with nitrilotriacetic acid (III) by means of pyridine and acetic anhydride.

参考文献中间体

合成目标

【1】 Nunn, A.; Loberg, M. (Bristol-Myers Squibb Co.); N-substituted iminodiacetic acids. BE 0891534; DE 3151686; FR 2497197; GB 2090252; JP 2160727; JP 58000948 .
【2】 Ashkinazi, R.I. (Natural Drug Sciences LLC); 5H-Pyrano[2,3-d:6,5-d']dipyrimidine derivs. having an antibacterial, antiviral and immuno-modulating activity. EP 1033369; US 6340755; WO 9925718 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	28804	2,4,6-trimethylaniline	88-05-1	C₉H₁₃N	详情	详情
(II)	28805	3-bromo-2,4,6-trimethylaniline	82842-52-2	C₉H₁₂BrN	详情	详情
(III)	28806	2-[bis(carboxymethyl)amino]acetic acid	139-13-9	C₆H₉NO₆	详情	详情

Extended Information