【结 构 式】 |
【药物名称】Mebrofenin, SQ-26962, Choletec 【化学名称】N-[2-[(3-Bromo-2,4,6-trimethylphenyl)amino]-2-oxoethyl]-N-(carboxymethyl)glycine 【CA登记号】78266-06-5 【 分 子 式 】C15H19BrN2O5 【 分 子 量 】387.23308 |
【开发单位】Bristol-Myers Squibb (Originator) 【药理作用】DIAGNOSTIC AGENTS |
合成路线1
The bromination of 2,4,6-trimethylaniline (I) with Br2 in aqueous HCl gives 3-bromo-2,4,6-trimethyl-aniline (II), which is then condensed with nitrilotriacetic acid (III) by means of pyridine and acetic anhydride.
【1】 Nunn, A.; Loberg, M. (Bristol-Myers Squibb Co.); N-substituted iminodiacetic acids. BE 0891534; DE 3151686; FR 2497197; GB 2090252; JP 2160727; JP 58000948 . |
【2】 Ashkinazi, R.I. (Natural Drug Sciences LLC); 5H-Pyrano[2,3-d:6,5-d']dipyrimidine derivs. having an antibacterial, antiviral and immuno-modulating activity. EP 1033369; US 6340755; WO 9925718 . |
Extended Information