3-amino-2,2-dimethyl-5-phenylpentanoic acid -Drug Synthesis Database

【结构式】

【分子编号】28656

【品名】3-amino-2,2-dimethyl-5-phenylpentanoic acid

【CA登记号】

【分子式】C₁₃H₁₉NO₂

【分子量】221.2994

【元素组成】C 70.56% H 8.65% N 6.33% O 14.46%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(I)

The acylation of 3-amino-2,2-dimethyl-5-phenylpentanoic acid (I) with benzoyl chloride (II) in pyridine gives the corresponding amide (III), which is finally converted into the target anhydride by reaction with bromo-tris-pyrrolidino-phosphonium hexafluorophosphate (PyBroP) and triethylamine in dichloromethane.

参考文献中间体

合成目标

【1】 Iijima, K.; Hayashi, Y.; Katada, J.; Symmetrical anhydride-type serine protease inhibitors: Structure-activity relationship studies of human chymase inhibitors. Bioorg Med Chem Lett 1999, 9, 3, 413.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	28656	3-amino-2,2-dimethyl-5-phenylpentanoic acid		C₁₃H₁₉NO₂	详情	详情
(II)	10463	Benzoyl chloride	98-88-4	C₇H₅ClO	详情	详情
(III)	28657	3-(benzoylamino)-2,2-dimethyl-5-phenylpentanoic acid		C₂₀H₂₃NO₃	详情	详情

Extended Information