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【结 构 式】 
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【药物名称】 【化学名称】(-)-2,2-Dimethyl-5-phenyl-3-(benzamido)pentanoic acid anhydride 【CA登记号】 【 分 子 式 】C40H44N2O5 【 分 子 量 】632.80708 |
【开发单位】Nippon Steel (Originator) 【药理作用】PHARMACOLOGICAL TOOLS, Chymase Inhibitors |
合成路线1
The acylation of 3-amino-2,2-dimethyl-5-phenylpentanoic acid (I) with benzoyl chloride (II) in pyridine gives the corresponding amide (III), which is finally converted into the target anhydride by reaction with bromo-tris-pyrrolidino-phosphonium hexafluorophosphate (PyBroP) and triethylamine in dichloromethane.
| 【1】 Iijima, K.; Hayashi, Y.; Katada, J.; Symmetrical anhydride-type serine protease inhibitors: Structure-activity relationship studies of human chymase inhibitors. Bioorg Med Chem Lett 1999, 9, 3, 413. |
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