4-[[2-(2-naphthyl)-4-quinolinyl]amino]phenol -Drug Synthesis Database

【结构式】

【分子编号】34399

【品名】4-[[2-(2-naphthyl)-4-quinolinyl]amino]phenol

【CA登记号】

【分子式】C₂₅H₁₈N₂O

【分子量】362.4308

【元素组成】C 82.85% H 5.01% N 7.73% O 4.41%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

The condensation of 4-chloro-2-(2-naphthyl)quinoline (I) with p-aminophenol (II) at 130 C provided the corresponding 4-anilinoquinoline (III). Then, Mannich reaction of (III) with N-methylpiperazine (IV) and formaldehyde furnished the title compound.

参考文献中间体

合成目标

【1】 Kotecka, B.M.; Strekowski, L.; Say, M.; Manzel, L.; Henary, M.; Zegrocka, O.; Macfarlane, D.E.; Mokrosz, M.J.; Structure-activity relationship analysis of substituted 4-quinolinamines, antagonists of immunostimulatory CpG-oligodeoxynucleotides. Bioorg Med Chem Lett 1999, 9, 13, 1819.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	34398	4-chloro-2-(2-naphthyl)quinoline		C₁₉H₁₂ClN	详情	详情
(II)	15715	4-Aminophenol	123-30-8	C₆H₇NO	详情	详情
(III)	34399	4-[[2-(2-naphthyl)-4-quinolinyl]amino]phenol		C₂₅H₁₈N₂O	详情	详情
(IV)	10061	1-Methylpiperazine; 1-Methyl piperazine; N-Methylpiperazine	109-01-3	C₅H₁₂N₂	详情	详情

Extended Information