|
【结 构 式】 
|
【药物名称】 【化学名称】N-[4-Hydroxy-3,5-bis(4-methylpiperazin-1-ylmethyl)phenyl]-2-(2-naphthyl)quinoline-4-amine 【CA登记号】 【 分 子 式 】C37H42N6O 【 分 子 量 】586.78689 |
【开发单位】Georgia State University (Originator), University of Iowa (Originator) 【药理作用】Antiarthritic Drugs, IMMUNOMODULATING AGENTS, Systemic Lupus Erythematosus, Agents for, Treatment of Autoimmune Diseases, TREATMENT OF MUSCULOSKELETAL & CONNECTIVE TISSUE DISEASES, Treatment of Other Autoimmune Disorders |
合成路线1
The condensation of 4-chloro-2-(2-naphthyl)quinoline (I) with p-aminophenol (II) at 130 C provided the corresponding 4-anilinoquinoline (III). Then, Mannich reaction of (III) with N-methylpiperazine (IV) and formaldehyde furnished the title compound.
| 【1】 Kotecka, B.M.; Strekowski, L.; Say, M.; Manzel, L.; Henary, M.; Zegrocka, O.; Macfarlane, D.E.; Mokrosz, M.J.; Structure-activity relationship analysis of substituted 4-quinolinamines, antagonists of immunostimulatory CpG-oligodeoxynucleotides. Bioorg Med Chem Lett 1999, 9, 13, 1819. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 34398 | 4-chloro-2-(2-naphthyl)quinoline | C19H12ClN | 详情 | 详情 | |
| (II) | 15715 | 4-Aminophenol | 123-30-8 | C6H7NO | 详情 | 详情 |
| (III) | 34399 | 4-[[2-(2-naphthyl)-4-quinolinyl]amino]phenol | C25H18N2O | 详情 | 详情 | |
| (IV) | 10061 | 1-Methylpiperazine; 1-Methyl piperazine; N-Methylpiperazine | 109-01-3 | C5H12N2 | 详情 | 详情 |
Extended Information