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【结 构 式】

【分子编号】33893

【品名】ethyl 2-[4-(1-[4-[1-(ethoxycarbonyl)propoxy]phenyl]cyclohexyl)phenoxy]butanoate

【CA登记号】

【 分 子 式 】C30H40O6

【 分 子 量 】496.644

【元素组成】C 72.55% H 8.12% O 19.33%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(III)

Compound can be prepared by several different ways: 1) By condensation of cyclohexylidenebis(4-hydroxyphenyl) (I) with 2-butanone (A) and CHCl3 by means of NaOH or KOH at 50-150 C. 2) By alkylation of cyclohexylidenebis(4,1-phenyleneoxy)bis(2-butanoic acid) diethyl ester (III) with NaH and methyl iodide in DMF to give the ester (IV), which is then hydrolyzed with K2CO3 in methanol. 3) By oxidation of cyclohexylidenebis(4,1-phenyleneoxy)bis(2-oxo-3-methyl-3-pentyl) (II) with sodium hypobromite or potassium hypochlorite in dioxane - water.

1 Nakamura, Y.; et al.; Phenoxy carboxylic acid derivative. BE 0748970; FR 2042333; US 3716583 .
2 Yoshitake, A.; et al.; JP 7354047 .
3 Nakamura, Y.; et al.; JP 7248378 .
4 Roberts, P.J.; Castaner, J.; S-8527. Drugs Fut 1977, 2, 5, 328.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(A) 33891 Methyl ethyl ketone; 2-Butanone 78-93-3 C4H8O 详情 详情
(I) 33890 4-[1-(4-hydroxyphenyl)cyclohexyl]phenol 843-55-0 C18H20O2 详情 详情
(II) 33892 3-(4-[1-[4-(1-ethyl-1-methyl-2-oxopropoxy)phenyl]cyclohexyl]phenoxy)-3-methyl-2-pentanone C30H40O4 详情 详情
(III) 33893 ethyl 2-[4-(1-[4-[1-(ethoxycarbonyl)propoxy]phenyl]cyclohexyl)phenoxy]butanoate C30H40O6 详情 详情
(IV) 33894 ethyl 2-[4-(1-[4-[1-(ethoxycarbonyl)-1-methylpropoxy]phenyl]cyclohexyl)phenoxy]-2-methylbutanoate C32H44O6 详情 详情
Extended Information