2-(2-hydroxyethyl)-2,5,7,8-tetramethyl-6-chromanol -Drug Synthesis Database

【结构式】

【分子编号】30838

【品名】2-(2-hydroxyethyl)-2,5,7,8-tetramethyl-6-chromanol

【CA登记号】

【分子式】C₁₅H₂₂O₃

【分子量】250.33788

【元素组成】C 71.97% H 8.86% O 19.17%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(I)

The title compound was prepared by coupling of 2-(3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)ethanol (I) with (S)-naproxen (II) by means of DCC and HOBt in acetonitrile.

参考文献中间体

合成目标

【1】 Hellberg, M.R.; Namil, A.; Delgado, P.; David, K.C.; Kessler, T.L.; Graff, G.; Haggard, K.S.; Nixon, J.C.; Novel esters and amides of nonsteroidal antiinflammatory carboxylic acids as antioxidants and antiproliferative agents. J Med Chem 1999, 42, 2, 267.
【2】 Hellberg, M.; Graff, G.; Gamache, D.A.; Nixon, J.C.; Garner, W.H. (Alcon Laboratories, Inc.); Esters and amides of non-steroidal anti-inflammatory carboxylic acids which may be used as anti-oxidants, 5-lipoxygenase inhibitors and non-steroidal anti-inflammatory products. EP 0799219; JP 1998511663; WO 9620187 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	30838	2-(2-hydroxyethyl)-2,5,7,8-tetramethyl-6-chromanol		C₁₅H₂₂O₃	详情	详情
(II)	30839	(2S)-2-(6-methoxy-2-naphthyl)propionic acid;(S)-naproxen;(S)-6-Methoxy-alpha-methyl-2-naphthaleneacetic acid	22204-53-1	C₁₄H₁₄O₃	详情	详情

Extended Information