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【结 构 式】 
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【药物名称】 【化学名称】2(S)-(6-Methoxynaphthalen-2-yl)propionic acid 2-(6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-1-benzopyran-2-yl)ethyl ester 【CA登记号】 【 分 子 式 】C29H34O5 【 分 子 量 】462.59133 |
【开发单位】Alcon (Originator) 【药理作用】Antiinflammatory Ophthalmic Agents, Ocular Antiinflammatory and Antiinfective Agents, OCULAR MEDICATIONS, Ophthalmic Drugs, Angiogenesis Inhibitors, Antioxidants, Non-Steroidal Antiinflammatory Drugs |
合成路线1
The title compound was prepared by coupling of 2-(3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)ethanol (I) with (S)-naproxen (II) by means of DCC and HOBt in acetonitrile.
| 【1】 Hellberg, M.R.; Namil, A.; Delgado, P.; David, K.C.; Kessler, T.L.; Graff, G.; Haggard, K.S.; Nixon, J.C.; Novel esters and amides of nonsteroidal antiinflammatory carboxylic acids as antioxidants and antiproliferative agents. J Med Chem 1999, 42, 2, 267. |
| 【2】 Hellberg, M.; Graff, G.; Gamache, D.A.; Nixon, J.C.; Garner, W.H. (Alcon Laboratories, Inc.); Esters and amides of non-steroidal anti-inflammatory carboxylic acids which may be used as anti-oxidants, 5-lipoxygenase inhibitors and non-steroidal anti-inflammatory products. EP 0799219; JP 1998511663; WO 9620187 . |
Extended Information