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【结 构 式】

【分子编号】28460

【品名】methyl (1S,4S,5S,10S)-4-benzyl-1,10-di(tert-butyl)-5-hydroxy-2,9,12-trioxo-7-[4-(2H-1,2,3,4-tetraazol-5-yl)benzyl]-13-oxa-3,7,8,11-tetraazatetradec-1-ylcarbamate

【CA登记号】

【 分 子 式 】C34H49N9O7

【 分 子 量 】695.81952

【元素组成】C 58.69% H 7.1% N 18.12% O 16.1%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(XIV)

Deprotection of the Boc group of XI) by treatment with HCl furnished hydrazine (XII), which was coupled with N-methoxycarbonyl-L-tert-leucine (X) to afford bisamide (XIII). The alpha,alpha-dimethyl benzyl protecting group of (XIII) was then removed with 80% H2SO4, and the deprotected tetrazole (XIV) was finally alkylated with CH3I to provide the title compound.

1 Fassler, A.; Bold, G.; Capraro, H.-G.; Lang, M.; Khanna, S.C. (Novartis AG); Antivirally active heterocyclic azahexane derivs.. EP 0900210; JP 1999511177; US 5849911; WO 9740029 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(X) 23447 (2S)-2-[(methoxycarbonyl)amino]-3,3-dimethylbutyric acid C8H15NO4 详情 详情
(XI) 28457 tert-butyl (5S,6S,9S)-6-benzyl-9-(tert-butyl)-5-hydroxy-3-[4-[2-(1-methyl-1-phenylethyl)-2H-1,2,3,4-tetraazol-5-yl]benzyl]-8,11-dioxo-12-oxa-2,3,7,10-tetraazatridecan-1-oate C40H54N8O6 详情 详情
(XII) 28458 methyl (1S)-1-([[(1S,2S)-1-benzyl-2-hydroxy-3-(1-[4-[2-(1-methyl-1-phenylethyl)-2H-1,2,3,4-tetraazol-5-yl]benzyl]hydrazino)propyl]amino]carbonyl)-2,2-dimethylpropylcarbamate C35H46N8O4 详情 详情
(XIII) 28459 methyl (1S,4S,5S,10S)-4-benzyl-1,10-di(tert-butyl)-5-hydroxy-7-[4-[2-(1-methyl-1-phenylethyl)-2H-1,2,3,4-tetraazol-5-yl]benzyl]-2,9,12-trioxo-13-oxa-3,7,8,11-tetraazatetradec-1-ylcarbamate C43H59N9O7 详情 详情
(XIV) 28460 methyl (1S,4S,5S,10S)-4-benzyl-1,10-di(tert-butyl)-5-hydroxy-2,9,12-trioxo-7-[4-(2H-1,2,3,4-tetraazol-5-yl)benzyl]-13-oxa-3,7,8,11-tetraazatetradec-1-ylcarbamate C34H49N9O7 详情 详情
Extended Information