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【结 构 式】 
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【分子编号】28154 【品名】5-(2-hydroxyethoxy)-2-(3-hydroxy-4-methoxyphenyl)-7-[[(2S,3R,4S,5S)-3,4,5-trihydroxy-6-([[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy]methyl)tetrahydro-2H-pyran-2-yl]oxy]-4H-chromen-4-one 【CA登记号】 |
【 分 子 式 】C30H36O16 【 分 子 量 】652.60624 【元素组成】C 55.21% H 5.56% O 39.23% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(IIIa)By reaction of diosmin (I) with 2-chloroethanol (II) in alkaline aqueous medium.
| 【1】 Mosquera, R.; Orjales, A. (FAES); Preparation of mono- and di-beta-hydroxyethyl diosmine mixture. DE 3715447; ES 554841; FR 2598415; IT 1215471 . |
| 【2】 Orjales, A.; Hidrosmin. Drugs Fut 1987, 12, 11, 1015. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (IIIa) | 28154 | 5-(2-hydroxyethoxy)-2-(3-hydroxy-4-methoxyphenyl)-7-[[(2S,3R,4S,5S)-3,4,5-trihydroxy-6-([[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy]methyl)tetrahydro-2H-pyran-2-yl]oxy]-4H-chromen-4-one | C30H36O16 | 详情 | 详情 | |
| (IIIb) | 28155 | 5-(2-hydroxyethoxy)-2-[3-(2-hydroxyethoxy)-4-methoxyphenyl]-7-[[(2S,3R,4S,5S)-3,4,5-trihydroxy-6-([[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy]methyl)tetrahydro-2H-pyran-2-yl]oxy]-4H-chromen-4-one | C32H40O17 | 详情 | 详情 | |
| (I) | 23461 | 5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-[[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-([[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy]methyl)tetrahydro-2H-pyran-2-yl]oxy]-4H-chromen-4-one | 520-27-4 | C28H32O15 | 详情 | 详情 |
| (II) | 10384 | 2-Chloro-1-ethanol; Ethylene chlorohydrin | 107-07-3 | C2H5ClO | 详情 | 详情 |
Extended Information