Hidrosmina, Hidrosmin, F-117, Venosmil, -Drug Synthesis Database

【结构式】

【药物名称】Hidrosmina, Hidrosmin, F-117, Venosmil

【化学名称】O-(beta-Hydroxyethyl)diosmin

【CA登记号】115960-14-0

【分子式】C₃₀H₃₈O₁₆

【分子量】654.62776

【开发单位】FAES (Originator)

【药理作用】Cardiovascular Diseases (Not Specified), CARDIOVASCULAR DRUGS

合成路线1

By reaction of diosmin (I) with 2-chloroethanol (II) in alkaline aqueous medium.

【1】 Mosquera, R.; Orjales, A. (FAES); Preparation of mono- and di-beta-hydroxyethyl diosmine mixture. DE 3715447; ES 554841; FR 2598415; IT 1215471 .
【2】 Orjales, A.; Hidrosmin. Drugs Fut 1987, 12, 11, 1015.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(IIIa)	28154	5-(2-hydroxyethoxy)-2-(3-hydroxy-4-methoxyphenyl)-7-[[(2S,3R,4S,5S)-3,4,5-trihydroxy-6-([[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy]methyl)tetrahydro-2H-pyran-2-yl]oxy]-4H-chromen-4-one		C₃₀H₃₆O₁₆	详情	详情
(IIIb)	28155	5-(2-hydroxyethoxy)-2-[3-(2-hydroxyethoxy)-4-methoxyphenyl]-7-[[(2S,3R,4S,5S)-3,4,5-trihydroxy-6-([[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy]methyl)tetrahydro-2H-pyran-2-yl]oxy]-4H-chromen-4-one		C₃₂H₄₀O₁₇	详情	详情
(I)	23461	5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-[[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-([[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy]methyl)tetrahydro-2H-pyran-2-yl]oxy]-4H-chromen-4-one	520-27-4	C₂₈H₃₂O₁₅	详情	详情
(II)	10384	2-Chloro-1-ethanol; Ethylene chlorohydrin	107-07-3	C₂H₅ClO	详情	详情

Extended Information