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【结 构 式】

【分子编号】28078

【品名】15-(4-iodophenyl)-1-pentadecanol

【CA登记号】

【 分 子 式 】C21H35IO

【 分 子 量 】430.41277

【元素组成】C 58.6% H 8.2% I 29.48% O 3.72%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(II)

Iodophenylpentadecanoic acid (I) was reduced to the corresponding alcohol (II) with borane in THF and then converted to the tosylate (III). Treatment of 3-(benzyloxy)propanol (IV) with CBr4 and PPh3 afforded bromide (V). This was treated with Mg in THF and the resulting Grignard reagent was coupled with tosylate (III) in the presence of Li2CuCl4 to provide octadecyl benzyl ether (VI), which was cleaved to the aryl octadecanol (VII) using AlCl3 and anisole. Reaction of alcohol (VII) with phospholane (VIII), followed by condensation with trimethylamine then furnished the title compound.

1 Weichert, J.P.; Rampy, M.A.; Counsell, R.E.; Longino, M.A.; Pinchuk, A.N. (University of Michigan); Radioiodinated phospholipid ether analogs and methods of using the same. WO 9824480 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 28077 15-(4-iodophenyl)pentadecanoic acid C21H33IO2 详情 详情
(II) 28078 15-(4-iodophenyl)-1-pentadecanol C21H35IO 详情 详情
(III) 28079 15-(4-iodophenyl)pentadecyl 4-methylbenzenesulfonate C28H41IO3S 详情 详情
(IV) 14687 3-(benzyloxy)-1-propanol; 3-(Benzyloxy)propanol 4799-68-2 C10H14O2 详情 详情
(V) 28080 1-[(3-bromopropoxy)methyl]benzene C10H13BrO 详情 详情
(VI) 28081 benzyl 18-(4-iodophenyl)octadecyl ether C31H47IO 详情 详情
(VII) 28081 benzyl 18-(4-iodophenyl)octadecyl ether C31H47IO 详情 详情
(VIII) 28082 18-(4-iodophenyl)-1-octadecanol C24H41IO 详情 详情
Extended Information