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【结 构 式】 
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【分子编号】28022 【品名】(2S)-1-acetyl-2-pyrrolidinecarboxylic acid 【CA登记号】68-95-1 |
【 分 子 式 】C7H11NO3 【 分 子 量 】157.16928 【元素组成】C 53.49% H 7.05% N 8.91% O 30.54% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(II)Optically active sulpiride is prepared by converting levo-proline (I) to the correspondig levorotatory acetylproline (II), followed by reduction, chlorination and amination to afford levorotatory N-ethyl-2-aminomethylpyrrolidine (V), which, upon treatment with an ester of 2-methoxy-5-sulfamoylbenzoic acid (VI), yields N-(1-ethyl-2-pyrrolidinomethyl)-2-methoxy-5-sulfamoylbenzamide, that is, the levorotatory enantiomer of sulpiride.
| 【1】 Forgione, A.; Levosulpiride. Drugs Fut 1987, 12, 10, 944. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 16731 | L-proline | 147-85-3 | C5H9NO2 | 详情 | 详情 |
| (II) | 28022 | (2S)-1-acetyl-2-pyrrolidinecarboxylic acid | 68-95-1 | C7H11NO3 | 详情 | 详情 |
| (III) | 28023 | [(2S)-1-ethylpyrrolidinyl]methanol | C7H15NO | 详情 | 详情 | |
| (IV) | 28024 | (2S)-2-(chloromethyl)-1-ethylpyrrolidine | C7H14ClN | 详情 | 详情 | |
| (V) | 21345 | (2S)-1-Ethyl-2-(aminomethyl)pyrrolidine; [(2S)-1-Ethylpyrrolidinyl]methanamine | C7H16N2 | 详情 | 详情 | |
| (VI) | 28025 | methyl 5-(aminosulfonyl)-2-methoxybenzoate | 33045-52-2 | C9H11NO5S | 详情 | 详情 |
Extended Information