methyl (2S)-2-[[4-[[(1H-imidazol-4-ylmethyl)amino]methyl]-2-(1-naphthyl)benzoyl]amino]-4-methylpentanoate -Drug Synthesis Database

【结构式】

【分子编号】27715

【品名】methyl (2S)-2-[[4-[[(1H-imidazol-4-ylmethyl)amino]methyl]-2-(1-naphthyl)benzoyl]amino]-4-methylpentanoate

【CA登记号】

【分子式】C₂₉H₃₂N₄O₃

【分子量】484.59824

【元素组成】C 71.88% H 6.66% N 11.56% O 9.9%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(XIV)

Further acidic treatment of compund (X) regenerated the amine, which was condensed with the imidazole aldehyde (XI) in the presence of titanium isopropoxide as the water scavenger to give imine (XII). This was reduced to amine (XIII) using NaBH3CN. Finally, the title compound was obtained after acid cleavage of the trityl group of (XXXIII), followed by hydrolysis of the resulting ester (XIV).

参考文献中间体

合成目标

【1】 Vasudevan, A.; et al.; Potent, highly selective, and non-thiol inhibitors of protein geranylgeranyltransferase-I. J Med Chem 1999, 42, 8, 1333.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(X)	27711	methyl (2S)-2-[[4-[[(tert-butoxycarbonyl)amino]methyl]-2-(1-naphthyl)benzoyl]amino]-4-methylpentanoate		C₃₀H₃₆N₂O₅	详情	详情
(XI)	27712	1-trityl-1H-imidazole-4-carbaldehyde；1-Tritylimidazole-4-carboxaldehyde	33016-47-6	C₂₃H₁₈N₂O	详情	详情
(XII)	27713	methyl (2S)-4-methyl-2-[[2-(1-naphthyl)-4-([[(E)-(1-trityl-1H-imidazol-4-yl)methylidene]amino]methyl)benzoyl]amino]pentanoate		C₄₈H₄₄N₄O₃	详情	详情
(XIII)	27714	methyl (2S)-4-methyl-2-[[2-(1-naphthyl)-4-([[(1-trityl-1H-imidazol-4-yl)methyl]amino]methyl)benzoyl]amino]pentanoate		C₄₈H₄₆N₄O₃	详情	详情
(XIV)	27715	methyl (2S)-2-[[4-[[(1H-imidazol-4-ylmethyl)amino]methyl]-2-(1-naphthyl)benzoyl]amino]-4-methylpentanoate		C₂₉H₃₂N₄O₃	详情	详情

Extended Information