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【结 构 式】

【分子编号】27713

【品名】methyl (2S)-4-methyl-2-[[2-(1-naphthyl)-4-([[(E)-(1-trityl-1H-imidazol-4-yl)methylidene]amino]methyl)benzoyl]amino]pentanoate

【CA登记号】

【 分 子 式 】C48H44N4O3

【 分 子 量 】724.90252

【元素组成】C 79.53% H 6.12% N 7.73% O 6.62%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(XII)

Further acidic treatment of compund (X) regenerated the amine, which was condensed with the imidazole aldehyde (XI) in the presence of titanium isopropoxide as the water scavenger to give imine (XII). This was reduced to amine (XIII) using NaBH3CN. Finally, the title compound was obtained after acid cleavage of the trityl group of (XXXIII), followed by hydrolysis of the resulting ester (XIV).

1 Vasudevan, A.; et al.; Potent, highly selective, and non-thiol inhibitors of protein geranylgeranyltransferase-I. J Med Chem 1999, 42, 8, 1333.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(X) 27711 methyl (2S)-2-[[4-[[(tert-butoxycarbonyl)amino]methyl]-2-(1-naphthyl)benzoyl]amino]-4-methylpentanoate C30H36N2O5 详情 详情
(XI) 27712 1-trityl-1H-imidazole-4-carbaldehyde;1-Tritylimidazole-4-carboxaldehyde 33016-47-6 C23H18N2O 详情 详情
(XII) 27713 methyl (2S)-4-methyl-2-[[2-(1-naphthyl)-4-([[(E)-(1-trityl-1H-imidazol-4-yl)methylidene]amino]methyl)benzoyl]amino]pentanoate C48H44N4O3 详情 详情
(XIII) 27714 methyl (2S)-4-methyl-2-[[2-(1-naphthyl)-4-([[(1-trityl-1H-imidazol-4-yl)methyl]amino]methyl)benzoyl]amino]pentanoate C48H46N4O3 详情 详情
(XIV) 27715 methyl (2S)-2-[[4-[[(1H-imidazol-4-ylmethyl)amino]methyl]-2-(1-naphthyl)benzoyl]amino]-4-methylpentanoate C29H32N4O3 详情 详情
Extended Information