benzyl 4-[(6,7-dimethoxy-3,4-dihydro-1-isoquinolinyl)methyl]phenyl ether -Drug Synthesis Database

【结构式】

【分子编号】27671

【品名】benzyl 4-[(6,7-dimethoxy-3,4-dihydro-1-isoquinolinyl)methyl]phenyl ether

【CA登记号】

【分子式】C₂₅H₂₅NO₃

【分子量】387.47844

【元素组成】C 77.49% H 6.5% N 3.61% O 12.39%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(I)

The methylation of the 1-(4-benzyloxybenzyl)-6,7-dimethoxy-3,4-dihydroisoquinoline (I) with methyl iodide gives the isoquinolinium salt (II), which is reduced with potassium borohydride to afford 1-(4-benzyloxybenzyl)-6,7-dimethoxy-2-methyl-3,4-dihydroisoquinoline (III). The treatment of (III) with HCl yields the phenol (IV), which is finally alkylated with 2-(4-nitrophenoxy)ethanol.

参考文献中间体

合成目标

【1】 He, L.W.; et al.; Synthesis and biological activity of 1-(4-alkyloxy)benzyl-1,2,3,4-tetrahydroisoquinolines and related compounds. Acta Pharm Sin 1998, 33, 10, 741.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	27671	benzyl 4-[(6,7-dimethoxy-3,4-dihydro-1-isoquinolinyl)methyl]phenyl ether		C₂₅H₂₅NO₃	详情	详情
(II)	27672	1-[4-(benzyloxy)benzyl]-6,7-dimethoxy-2-methyl-3,4-dihydroisoquinolinium iodide		C₂₆H₂₈INO₃	详情	详情
(III)	27673	1-[4-(benzyloxy)benzyl]-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline		C₂₆H₂₉NO₃	详情	详情
(IV)	27674	4-[(6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydro-1-isoquinolinyl)methyl]phenol		C₁₉H₂₃NO₃	详情	详情
(V)	12396	2-Chloroethyl 4-nitrophenyl ether; 1-(2-Chloroethoxy)-4-nitrobenzene	3383-72-0	C₈H₈ClNO₃	详情	详情

Extended Information