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【结 构 式】 
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【药物名称】 【化学名称】6,7-Dimethoxy-2-methyl-1-[4-[2-(4-nitrophenoxy)ethoxy]benzyl}-1,2,3,4-tetrahydroisoquinoline hydrochloride 【CA登记号】 【 分 子 式 】C27H31ClN2O6 【 分 子 量 】515.01092 |
【开发单位】China Pharmaceutical University (Originator) 【药理作用】Antiarrhythmic Drugs, CARDIOVASCULAR DRUGS |
合成路线1
The methylation of the 1-(4-benzyloxybenzyl)-6,7-dimethoxy-3,4-dihydroisoquinoline (I) with methyl iodide gives the isoquinolinium salt (II), which is reduced with potassium borohydride to afford 1-(4-benzyloxybenzyl)-6,7-dimethoxy-2-methyl-3,4-dihydroisoquinoline (III). The treatment of (III) with HCl yields the phenol (IV), which is finally alkylated with 2-(4-nitrophenoxy)ethanol.
| 【1】 He, L.W.; et al.; Synthesis and biological activity of 1-(4-alkyloxy)benzyl-1,2,3,4-tetrahydroisoquinolines and related compounds. Acta Pharm Sin 1998, 33, 10, 741. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 27671 | benzyl 4-[(6,7-dimethoxy-3,4-dihydro-1-isoquinolinyl)methyl]phenyl ether | C25H25NO3 | 详情 | 详情 | |
| (II) | 27672 | 1-[4-(benzyloxy)benzyl]-6,7-dimethoxy-2-methyl-3,4-dihydroisoquinolinium iodide | C26H28INO3 | 详情 | 详情 | |
| (III) | 27673 | 1-[4-(benzyloxy)benzyl]-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline | C26H29NO3 | 详情 | 详情 | |
| (IV) | 27674 | 4-[(6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydro-1-isoquinolinyl)methyl]phenol | C19H23NO3 | 详情 | 详情 | |
| (V) | 12396 | 2-Chloroethyl 4-nitrophenyl ether; 1-(2-Chloroethoxy)-4-nitrobenzene | 3383-72-0 | C8H8ClNO3 | 详情 | 详情 |
Extended Information