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【结 构 式】 
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【分子编号】27668 【品名】2-amino-6-(bromomethyl)-5-methylpyrido[2,3-d]pyrimidin-4-ylamine 【CA登记号】 |
【 分 子 式 】C9H10BrN5 【 分 子 量 】268.1161 【元素组成】C 40.32% H 3.76% Br 29.8% N 26.12% |
与该中间体有关的原料药合成路线共 2 条
合成路线1
该中间体在本合成路线中的序号：(I)By coBy condensation of bromomethyl derivative (I) with aniline (II). ndensation of bromomethyl derivative (I) with aniline (II).
| 【1】 Carter, R.L.; Borotz, S.E.; Krauth, C.A.; Queener, S.F.; Piper, J.R.; Pfefferkorn, E.R.; Hosmer, C.A.; Johnson, C.A.; Lipophilic antifolates as agents against opportunistic infections. 1. Agents superior to trimetrexate and piritrexim against Toxoplasma gondii and Pneumocystis carinii in in vitro evaluations. J Med Chem 1996, 39, 6, 1271. |
合成路线2
该中间体在本合成路线中的序号：(I)By condensation of bromomethyl derivative (I) with aniline (II).
| 【1】 Carter, R.L.; Borotz, S.E.; Krauth, C.A.; Queener, S.F.; Piper, J.R.; Pfefferkorn, E.R.; Hosmer, C.A.; Johnson, C.A.; Lipophilic antifolates as agents against opportunistic infections. 1. Agents superior to trimetrexate and piritrexim against Toxoplasma gondii and Pneumocystis carinii in in vitro evaluations. J Med Chem 1996, 39, 6, 1271. |
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