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【结 构 式】 
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【药物名称】SRI-8228 【化学名称】6-[2-Methoxy-5-(trifluoromethyl)phenylaminomethyl]-5-methylpyrido[2,3-d]pyrimidine-2,4-diamine 【CA登记号】174654-98-9 【 分 子 式 】C17H17F3N6O 【 分 子 量 】378.35984 |
【开发单位】Southern Research Institute (Originator) 【药理作用】AIDS Medicines, ANTIINFECTIVE THERAPY, Treatment of Opportunistic Infections, Treatment of Protozoal Diseases, Dihydrofolate Reductase (DHFR) Inhibitors |
合成路线1
By condensation of bromomethyl derivative (I) with aniline (II).
| 【1】 Carter, R.L.; Borotz, S.E.; Krauth, C.A.; Queener, S.F.; Piper, J.R.; Pfefferkorn, E.R.; Hosmer, C.A.; Johnson, C.A.; Lipophilic antifolates as agents against opportunistic infections. 1. Agents superior to trimetrexate and piritrexim against Toxoplasma gondii and Pneumocystis carinii in in vitro evaluations. J Med Chem 1996, 39, 6, 1271. |
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