4-(chlorocarbonyl)phenyl ethyl carbonate -Drug Synthesis Database

【结构式】

【分子编号】27371

【品名】4-(chlorocarbonyl)phenyl ethyl carbonate

【CA登记号】

【分子式】C₁₀H₉ClO₄

【分子量】228.63176

【元素组成】C 52.53% H 3.97% Cl 15.51% O 27.99%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(II)

4-(4-isopropylpiperazinocarbonyl)phenol (IV) is obtained by reaction of 1-isopropylpiperazine (I) and 4-ethoxycarbonyloxybenzoylchloride (II) in CHCl3 using triethylamine (Et3N) as a proton scavenger, followed by removing its ethoxycarbonyl group using pyrrolidine in ethylacetate. Also, the reaction in CHCl3 of 1,2,3,4-tetrahydro-1-naphtoyl chloride (III) and (IV) using Et3N, followed by neutralization of the medium using NaOH and by salt formation using CH3SO3H in ethanol, yields FK-448.

参考文献中间体

合成目标

【1】 Fujii, S.; Hattori, E.; Hirata, M.; Watanabe, K.; Onogi, K.; Nagakura, M. (Kowa Co., Ltd.); Benzoylpiperazine esters and a process for their production. EP 0098713; JP 83225080; US 4898876 .
【2】 Prous, J.; Castaner, J.; FK-448. Drugs Fut 1986, 11, 3, 185.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(A)	11376	Pyrrolidine	123-75-1	C₄H₉N	详情	详情
(I)	27370	1-isopropylpiperazine		C₇H₁₆N₂	详情	详情
(II)	27371	4-(chlorocarbonyl)phenyl ethyl carbonate		C₁₀H₉ClO₄	详情	详情
(III)	27373	1,2,3,4-tetrahydro-1-naphthalenecarbonyl chloride		C₁₁H₁₁ClO	详情	详情
(IV)	27372	(4-hydroxyphenyl)(4-isopropyl-1-piperazinyl)methanone		C₁₄H₂₀N₂O₂	详情	详情

Extended Information