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【结 构 式】 
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【药物名称】FK-448 【化学名称】1,2,3,4-Tetrahydro-1-naphthalenecarboxylic acid 4-[[4-(1-methylethyl)-1-piperazinyl]carbonyl]phenyl ester monomethanesulfonate 【CA登记号】89703-10-6 【 分 子 式 】C26H34N2O6S 【 分 子 量 】502.63468 |
【开发单位】Kowa (Originator) 【药理作用】Chymotrypsin Inhibitors, Protease Inhibitors |
合成路线1
4-(4-isopropylpiperazinocarbonyl)phenol (IV) is obtained by reaction of 1-isopropylpiperazine (I) and 4-ethoxycarbonyloxybenzoylchloride (II) in CHCl3 using triethylamine (Et3N) as a proton scavenger, followed by removing its ethoxycarbonyl group using pyrrolidine in ethylacetate. Also, the reaction in CHCl3 of 1,2,3,4-tetrahydro-1-naphtoyl chloride (III) and (IV) using Et3N, followed by neutralization of the medium using NaOH and by salt formation using CH3SO3H in ethanol, yields FK-448.
| 【1】 Fujii, S.; Hattori, E.; Hirata, M.; Watanabe, K.; Onogi, K.; Nagakura, M. (Kowa Co., Ltd.); Benzoylpiperazine esters and a process for their production. EP 0098713; JP 83225080; US 4898876 . |
| 【2】 Prous, J.; Castaner, J.; FK-448. Drugs Fut 1986, 11, 3, 185. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (A) | 11376 | Pyrrolidine | 123-75-1 | C4H9N | 详情 | 详情 |
| (I) | 27370 | 1-isopropylpiperazine | C7H16N2 | 详情 | 详情 | |
| (II) | 27371 | 4-(chlorocarbonyl)phenyl ethyl carbonate | C10H9ClO4 | 详情 | 详情 | |
| (III) | 27373 | 1,2,3,4-tetrahydro-1-naphthalenecarbonyl chloride | C11H11ClO | 详情 | 详情 | |
| (IV) | 27372 | (4-hydroxyphenyl)(4-isopropyl-1-piperazinyl)methanone | C14H20N2O2 | 详情 | 详情 |