【结 构 式】 |
【分子编号】27354 【品名】1,3-dibutyl-3,7-dihydro-1H-purine-2,6-dione 【CA登记号】 |
【 分 子 式 】C13H20N4O2 【 分 子 量 】264.32756 【元素组成】C 59.07% H 7.63% N 21.2% O 12.11% |
与该中间体有关的原料药合成路线共 2 条
合成路线1
该中间体在本合成路线中的序号:(I)By condensation of the sodium salt of 1,3-dibutyl-xantine (I) with chloroacetone (II) in refluxing ethanol.
【1】 Rohte, O.; Khan, E.A.; Tauscher, M.; Brenner, G.; Goring, J. (SmithKline Beecham plc); 7-(Oxoalkyl)-1,3-dialkyl xanthines, and medicaments containing then. DE 2402908; DE 2462367 . |
【2】 Adams, J.L.; Gallagher, T.F.; Garigipati, R.S.; Boehm, J.C.; Sisko, J.; Peng, Z.-Q.; Lee, J.C.-L. (SmithKline Beecham plc); Certain 1,4,5-tri-substd. imidazole cpds. useful as cytokine. EP 0809499; JP 1998512555; US 5593992; WO 9621452 . |
【3】 Castaner, J.; Koch, H.; BRL-30892. Drugs Fut 1985, 10, 10, 809. |
合成路线2
该中间体在本合成路线中的序号:(I)The title compound was prepared by condensation of 1,3-dibutylxanthine (I) with 3-chloropropylsulfonyl chloride (II) in the presence of diisopropyl ethylamine.
【1】 Roberts, D.; Gilbert, A.M.; Caltabiano, S.; et al.; Novel and selective calcitonin-inducing agents. J Med Chem 2000, 43, 6, 1223. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 27354 | 1,3-dibutyl-3,7-dihydro-1H-purine-2,6-dione | C13H20N4O2 | 详情 | 详情 | |
(II) | 39225 | g-Chloropropanesulfonyl chloride;3-Chloropropansulfonyl chloride;1-Chloro-3-propanesulfonylchloride;3-Chloropropanesulfonyl chloride;3-chloro-1-propanesulfonyl chloride;3-chloropropane-1-sulfonyl chloride | 1633-82-5 | C3H6Cl2O2S | 详情 | 详情 |
Extended Information