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【结 构 式】 
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【药物名称】Denbufylline, BRL-30892 【化学名称】1,3-Dibutyl-7-(2-oxopropyl)-3,7-dihydro-1H-purine-2,6-dione 【CA登记号】57076-71-8 【 分 子 式 】C16H24N4O3 【 分 子 量 】320.39468 |
【开发单位】GlaxoSmithKline (Originator) 【药理作用】Antiallergy/Antiasthmatic Drugs, Asthma Therapy, Cardiovascular Diseases (Not Specified), CARDIOVASCULAR DRUGS, Cerebrovascular Diseases, Treatment of, Cognition Disorders, Treatment of, Ischemic Stroke, Treatment of, NEUROLOGIC DRUGS, RESPIRATORY DRUGS, Stroke, Treatment of, Phosphodiesterase IV Inhibitors |
合成路线1
By condensation of the sodium salt of 1,3-dibutyl-xantine (I) with chloroacetone (II) in refluxing ethanol.
| 【1】 Rohte, O.; Khan, E.A.; Tauscher, M.; Brenner, G.; Goring, J. (SmithKline Beecham plc); 7-(Oxoalkyl)-1,3-dialkyl xanthines, and medicaments containing then. DE 2402908; DE 2462367 . |
| 【2】 Adams, J.L.; Gallagher, T.F.; Garigipati, R.S.; Boehm, J.C.; Sisko, J.; Peng, Z.-Q.; Lee, J.C.-L. (SmithKline Beecham plc); Certain 1,4,5-tri-substd. imidazole cpds. useful as cytokine. EP 0809499; JP 1998512555; US 5593992; WO 9621452 . |
| 【3】 Castaner, J.; Koch, H.; BRL-30892. Drugs Fut 1985, 10, 10, 809. |
Extended Information