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【结 构 式】 
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【分子编号】27349 【品名】2-([[(6aR,10aR)-7-methyl-4,6,6a,7,8,10a-hexahydroindolo[4,3-fg]quinolin-9-yl]methyl]amino)-1-ethanol 【CA登记号】 |
【 分 子 式 】C18H23N3O 【 分 子 量 】297.40024 【元素组成】C 72.7% H 7.8% N 14.13% O 5.38% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(III)Elimoclavine (I) obtained by fermentation is first O-mesylated and then the mesyl group in the product (II) displaced by 2-aminoethanol to give the hydroxyethylamino derivative (III). Repeated acylation of (III) with mesyl chloride affords the N,O-dimesylate (IV), which exchanges the O-mesyl group for an azido group on treatment with sodium azide to give the base (VI). Salt formation with maleic acid gives RGH-7825 (1,2).
| 【1】 Mago, N.K.E.; et al. (Gedeon Richter Ltd.); Novel ergol-8-ene and ergolin compounds and process for preparing same. DE 3026271; HU 180467 . |
| 【2】 Nogradi, M.; RGH-7825. Drugs Fut 1985, 10, 9, 753. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (B) | 10259 | Ethanol amine;Ethanolamine;2-Aminoethanol; 2-Amino-1-ethanol；2-Aminoethyl alcohol | 141-43-5 | C2H7NO | 详情 | 详情 |
| (A) | 27347 | N,N-dicyclohexylamine | 101-83-7 | C12H23N | 详情 | 详情 |
| (I) | 27346 | [(6aR,10aR)-7-methyl-4,6,6a,7,8,10a-hexahydroindolo[4,3-fg]quinolin-9-yl]methanol | C16H18N2O | 详情 | 详情 | |
| (II) | 27348 | [(6aR,10aR)-7-methyl-4,6,6a,7,8,10a-hexahydroindolo[4,3-fg]quinolin-9-yl]methyl methanesulfonate | C17H20N2O3S | 详情 | 详情 | |
| (III) | 27349 | 2-([[(6aR,10aR)-7-methyl-4,6,6a,7,8,10a-hexahydroindolo[4,3-fg]quinolin-9-yl]methyl]amino)-1-ethanol | C18H23N3O | 详情 | 详情 | |
| (IV) | 27350 | 2-[[[(6aR,10aR)-7-methyl-4,6,6a,7,8,10a-hexahydroindolo[4,3-fg]quinolin-9-yl]methyl](methylsulfonyl)amino]ethyl methanesulfonate | C20H27N3O5S2 | 详情 | 详情 | |
| (V) | 27351 | N-[[(6aR,10aR)-7-methyl-4,6,6a,7,8,10a-hexahydroindolo[4,3-fg]quinolin-9-yl]methyl]-N-(2-azidoethyl)methanesulfonamide | C19H24N6O2S | 详情 | 详情 | |
| (VI) | 23808 | Fumaric acid; (E)-2-butenedioic acid | 110-17-8 | C4H4O4 | 详情 | 详情 |
Extended Information