2-phenyl-4-[(Z)-benzylidene]-1,3-oxazol-5-one -Drug Synthesis Database

【结构式】

【分子编号】27237

【品名】2-phenyl-4-[(Z)-benzylidene]-1,3-oxazol-5-one

【CA登记号】

【分子式】C₁₆H₁₁NO₂

【分子量】249.26888

【元素组成】C 77.1% H 4.45% N 5.62% O 12.84%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

Condensation of benzaldehyde (I) with hippuric acid (II) in the presence of NaOAc in boiling Ac2O furnished oxazolone (III). The title compound was then obtained by ring opening of (III) with piperidine (IV) in chloroform at 0 C, followed by chlorination with Cl2 gas.

参考文献中间体

合成目标

【1】 Conway, S.C.; Perni, R.B. (Avid Corp.); 2-Benzoylamino-3-phenylpropenamide derivs. and methods of using the same. WO 9833501 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	10498	Benzaldehyde;Benzoic aldehyde;Phenylmethanal	100-52-7	C₇H₆O	详情	详情
(II)	27236	2-(benzoylamino)acetic acid	495-69-2	C₉H₉NO₃	详情	详情
(III)	27237	2-phenyl-4-[(Z)-benzylidene]-1,3-oxazol-5-one		C₁₆H₁₁NO₂	详情	详情
(IV)	10158	Piperidine	110-89-4	C₅H₁₁N	详情	详情

Extended Information