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【结 构 式】 
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【药物名称】AT-61 【化学名称】(E)-N-[2-Chloro-2-phenyl-1-(piperidin-1-ylcarbonyl)vinyl]benzamide 【CA登记号】211363-59-6 【 分 子 式 】C21H21ClN2O2 【 分 子 量 】368.86672 |
【开发单位】Gilead (Originator) 【药理作用】Anti-Hepatitis B Virus Drugs, Anti-Hepatitis Virus Drugs, ANTIINFECTIVE THERAPY, Antiviral Drugs |
合成路线1
Condensation of benzaldehyde (I) with hippuric acid (II) in the presence of NaOAc in boiling Ac2O furnished oxazolone (III). The title compound was then obtained by ring opening of (III) with piperidine (IV) in chloroform at 0 C, followed by chlorination with Cl2 gas.
| 【1】 Conway, S.C.; Perni, R.B. (Avid Corp.); 2-Benzoylamino-3-phenylpropenamide derivs. and methods of using the same. WO 9833501 . |
Extended Information