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【结 构 式】

【分子编号】27030

【品名】5-isopropyl-2,4(1H,3H)-pyrimidinedione

【CA登记号】

【 分 子 式 】C7H10N2O2

【 分 子 量 】154.16868

【元素组成】C 54.54% H 6.54% N 18.17% O 20.76%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(VII)

The reaction of 5-isopropyluracil (VII) with chloromethyl ethyl ether (II) by means of bis(trimethylsilyl)acetamide (BSA) and tetrabutylammonium iodide (TBI) in dichloromethane gives 1-(ethoxy-methyl)-5-isopropyluracil (VIII)(3), which is then condensed with benzaldehyde (IV) by means of LDA in THF to afford 1-(ethoxymethyl)-5-isopropyl-6-(alpha-hydroxybenzyl)uracil (V), already obtained.

1 Ubasawa, M.; Yuasa, S. (Mitsubishi Chemical Corp.); Antiviral combinations of 2',3'-dideoxyribonucleosides with 6-benzyl-1-ethoxymethyl-5-substd. uracil derivs.. EP 0631783; JP 1995097324 .
2 Ubasawa, M.; et al. (Mitsubishi Chemical Corp.); Production of 6-aralkyl substituted pyrimidine derivative. JP 1996003143 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 27029 trimethylsilyl 4-[(trimethylsilyl)methyl]-2-pyrimidinyl sulfide C11H22N2SSi2 详情 详情
(II) 13149 1-(Chloromethoxy)ethane; Chloromethyl ethyl ether 3188-13-4 C3H7ClO 详情 详情
(IV) 10498 Benzaldehyde;Benzoic aldehyde;Phenylmethanal 100-52-7 C7H6O 详情 详情
(V) 27027 1-(ethoxymethyl)-6-[hydroxy(phenyl)methyl]-5-isopropyl-2,4(1H,3H)-pyrimidinedione C17H22N2O4 详情 详情
(VI) 27028 [3-(ethoxymethyl)-5-isopropyl-2,6-dioxo-1,2,3,6-tetrahydro-4-pyrimidinyl](phenyl)methyl acetate C19H24N2O5 详情 详情
(VII) 27030 5-isopropyl-2,4(1H,3H)-pyrimidinedione C7H10N2O2 详情 详情
(VIII) 27031 1-(ethoxymethyl)-5-isopropyl-2,4(1H,3H)-pyrimidinedione C10H16N2O3 详情 详情
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