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【结 构 式】 
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【分子编号】27029 【品名】trimethylsilyl 4-[(trimethylsilyl)methyl]-2-pyrimidinyl sulfide 【CA登记号】 |
【 分 子 式 】C11H22N2SSi2 【 分 子 量 】270.54616 【元素组成】C 48.83% H 8.2% N 10.35% S 11.85% Si 20.76% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(I)The reaction of 5-isopropyluracil (VII) with chloromethyl ethyl ether (II) by means of bis(trimethylsilyl)acetamide (BSA) and tetrabutylammonium iodide (TBI) in dichloromethane gives 1-(ethoxy-methyl)-5-isopropyluracil (VIII)(3), which is then condensed with benzaldehyde (IV) by means of LDA in THF to afford 1-(ethoxymethyl)-5-isopropyl-6-(alpha-hydroxybenzyl)uracil (V), already obtained.
| 【1】 Ubasawa, M.; Yuasa, S. (Mitsubishi Chemical Corp.); Antiviral combinations of 2',3'-dideoxyribonucleosides with 6-benzyl-1-ethoxymethyl-5-substd. uracil derivs.. EP 0631783; JP 1995097324 . |
| 【2】 Ubasawa, M.; et al. (Mitsubishi Chemical Corp.); Production of 6-aralkyl substituted pyrimidine derivative. JP 1996003143 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 27029 | trimethylsilyl 4-[(trimethylsilyl)methyl]-2-pyrimidinyl sulfide | C11H22N2SSi2 | 详情 | 详情 | |
| (II) | 13149 | 1-(Chloromethoxy)ethane; Chloromethyl ethyl ether | 3188-13-4 | C3H7ClO | 详情 | 详情 |
| (IV) | 10498 | Benzaldehyde;Benzoic aldehyde;Phenylmethanal | 100-52-7 | C7H6O | 详情 | 详情 |
| (V) | 27027 | 1-(ethoxymethyl)-6-[hydroxy(phenyl)methyl]-5-isopropyl-2,4(1H,3H)-pyrimidinedione | C17H22N2O4 | 详情 | 详情 | |
| (VI) | 27028 | [3-(ethoxymethyl)-5-isopropyl-2,6-dioxo-1,2,3,6-tetrahydro-4-pyrimidinyl](phenyl)methyl acetate | C19H24N2O5 | 详情 | 详情 | |
| (VII) | 27030 | 5-isopropyl-2,4(1H,3H)-pyrimidinedione | C7H10N2O2 | 详情 | 详情 | |
| (VIII) | 27031 | 1-(ethoxymethyl)-5-isopropyl-2,4(1H,3H)-pyrimidinedione | C10H16N2O3 | 详情 | 详情 |
Extended Information