2,2-difluoro-2-(4-isobutylphenyl)acetyl chloride -Drug Synthesis Database

【结构式】

【分子编号】27009

【品名】2,2-difluoro-2-(4-isobutylphenyl)acetyl chloride

【CA登记号】

【分子式】C₁₂H₁₃ClF₂O

【分子量】246.6841264

【元素组成】C 58.43% H 5.31% Cl 14.37% F 15.4% O 6.49%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(II)

The reaction of 2,2-difluoro-2-(4-isobutylphenyl)acetic acid (I) with oxalyl chloride in dichloromethane gives the corresponding acyl chloride (II), which is then treated with 6-methyl-2,4-bis(methylsulfanyl)pyridine-3-amine (III) and 4-(dimethylamino)pyridine (DMAP) in the same solvent.

参考文献中间体

合成目标

【1】 Ko, S.S.; Wilde, R.G.; DeLucca, I.; Li, H.-Y.; Kezar, H.S. III; Boswell, G.A.; Srivastava, A.S. (DuPont Pharmaceuticals Co.); Amides for the treatment of atherosclerosis. US 5583147 .

中间体序号	中间体编号	品名	分子式	供应商	用于合成
(I)	27008	2,2-difluoro-2-(4-isobutylphenyl)acetic acid	C₁₂H₁₄F₂O₂	详情	详情
(II)	27009	2,2-difluoro-2-(4-isobutylphenyl)acetyl chloride	C₁₂H₁₃ClF₂O	详情	详情
(III)	22239	6-methyl-2,4-bis(methylsulfanyl)-3-pyridinylamine; 6-methyl-2,4-bis(methylsulfanyl)-3-pyridinamine	C₈H₁₂N₂S₂	详情	详情

Extended Information