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【结 构 式】 
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【药物名称】XQ-786 【化学名称】2,2-Difluoro-2-(4-isobutylphenyl)-N-[6-methyl-2,4-bis(methylsulfanyl)-3-pyridinyl]acetamide 【CA登记号】186024-90-8 【 分 子 式 】C20H24F2N2OS2 【 分 子 量 】410.55188 |
【开发单位】Bristol-Myers Squibb (Originator) 【药理作用】Lipoprotein Disorders, Treatment of , METABOLIC DRUGS, ACAT Inhibitors |
合成路线1
The reaction of 2,2-difluoro-2-(4-isobutylphenyl)acetic acid (I) with oxalyl chloride in dichloromethane gives the corresponding acyl chloride (II), which is then treated with 6-methyl-2,4-bis(methylsulfanyl)pyridine-3-amine (III) and 4-(dimethylamino)pyridine (DMAP) in the same solvent.
| 【1】 Ko, S.S.; Wilde, R.G.; DeLucca, I.; Li, H.-Y.; Kezar, H.S. III; Boswell, G.A.; Srivastava, A.S. (DuPont Pharmaceuticals Co.); Amides for the treatment of atherosclerosis. US 5583147 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 27008 | 2,2-difluoro-2-(4-isobutylphenyl)acetic acid | C12H14F2O2 | 详情 | 详情 | |
| (II) | 27009 | 2,2-difluoro-2-(4-isobutylphenyl)acetyl chloride | C12H13ClF2O | 详情 | 详情 | |
| (III) | 22239 | 6-methyl-2,4-bis(methylsulfanyl)-3-pyridinylamine; 6-methyl-2,4-bis(methylsulfanyl)-3-pyridinamine | C8H12N2S2 | 详情 | 详情 |
Extended Information