N-hexyl-N'-phenylurea -Drug Synthesis Database

【结构式】

【分子编号】26547

【品名】N-hexyl-N'-phenylurea

【CA登记号】

【分子式】C₁₃H₂₀N₂O

【分子量】220.31468

【元素组成】C 70.87% H 9.15% N 12.72% O 7.26%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

The intermediate sulfonyl chloride (IV) was prepared by condensation of phenyl isocyanate (I) with n-hexylamine (II), followed by chlorosulfonation of the resulting hexyl phenyl urea (III) with ClSO3H at 60 C.

参考文献中间体

合成目标

【1】 Fisher, M.H.; Naylor, E.M.; Ok, D.; Weber, A.E.; Shih, T.; Ok, H. (Merck & Co., Inc.); Substd. sulfonamides as selective beta3 agonists for the treatment of diabetes and obesity. EP 0757674; JP 1997512275; US 5541197; US 5561142; WO 9529159 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
	29008	Chlorosulfonic acid	7790-94-5	HClO₃S	详情	详情
(I)	11289	1-Isocyanatobenzene; phenyl isocyanate; Phenylisocyanate	103-71-9	C₇H₅NO	详情	详情
(II)	26546	n-hexylamine; hexylamine	111-26-2	C₆H₁₅N	详情	详情
(III)	26547	N-hexyl-N'-phenylurea		C₁₃H₂₀N₂O	详情	详情
(IV)	26548	4-[[(hexylamino)carbonyl]amino]benzenesulfonyl chloride		C₁₃H₁₉ClN₂O₃S	详情	详情

Extended Information