tert-butyl (2S)-2-[[(2-iodo-3-pyridinyl)oxy]methyl]-1-azetidinecarboxylate -Drug Synthesis Database

【结构式】

【分子编号】26211

【品名】tert-butyl (2S)-2-[[(2-iodo-3-pyridinyl)oxy]methyl]-1-azetidinecarboxylate

【CA登记号】

【分子式】C₁₄H₁₉IN₂O₃

【分子量】390.22101

【元素组成】C 43.09% H 4.91% I 32.52% N 7.18% O 12.3%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(VIII)

In an alternative procedure, Mitsunobu coupling of alcohol (III) with 3-hydroxy-2-iodopyridine (VII) provided ether (VIII). The iodo atom of (III) was then displaced using [18F]KF-Kryptofix K222 complex in DMSO to provide radiolabeled precursor (VI), which was finally deprotected with trifluoroacetic acid.

参考文献中间体

合成目标

【1】 Hrti, A.; et al.; Synthesis of a radiotracer for studying nicotinic acetylcholine receptors: 2-[18F]fluoro-3-(2(S)-azetidinylmethoxy)pyridine (2-[18F]A85380). J Label Compd Radiopharm 1998, 41, 309-318.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(III)	26206	tert-butyl (2S)-2-(hydroxymethyl)-1-azetidinecarboxylate		C₉H₁₇NO₃	详情	详情
(VI)	26209	tert-butyl (2S)-2-[[(2-fluoro-3-pyridinyl)oxy]methyl]-1-azetidinecarboxylate		C₁₄H₁₉FN₂O₃	详情	详情
(VI)	26215	tert-butyl (2S)-2-[[(2-fluoro-3-pyridinyl)oxy]methyl]-1-azetidinecarboxylate		C₁₄H₁₉FN₂O₃	详情	详情
(VII)	26210	2-iodo-3-pyridinol	40263-57-8	C₅H₄INO	详情	详情
(VIII)	26211	tert-butyl (2S)-2-[[(2-iodo-3-pyridinyl)oxy]methyl]-1-azetidinecarboxylate		C₁₄H₁₉IN₂O₃	详情	详情

Extended Information