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【结 构 式】 
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【分子编号】25944 【品名】7-(2-aminoethyl)-4-hydroxy-1,3-benzothiazol-2(3H)-one 【CA登记号】 |
【 分 子 式 】C9H10N2O2S 【 分 子 量 】210.25668 【元素组成】C 51.41% H 4.79% N 13.32% O 15.22% S 15.25% |
合成路线1
该中间体在本合成路线中的序号：(VIII)The reaction of 3-bromopropanol (I) with thiourea in refluxing water gives 3-sulfanylpropanol (II), which is cyclized with 2-phenylacetaldehyde (III) by means of p-toluenesulfonic acid in refluxing toluene yielding 2-benzyl-1,3-oxathiane (IV). The reductive cleavage of (IV) with Ca in liquid ammonia affords 3-(2-phenylethoxy)propanethiol (V), which is condensed with bromoacetic acid by means of NaH in DMF providing 2-[3-(2-phenylethoxy)propylsulfanyl]acetic acid (VI). The oxidation of (VI) with potassium peroxymonosulfate (oxone) gives the corresponding sulfonylacetic acid (VII), which is condensed with benzothiazolone (VIII) by means of DCC, HOBT and triethylamine in DMF yielding the correponding amide (IX). Finally, this compound is reduced with borane/THF yielding the target compound.
| 【1】 Bonnert, R.V.; Brown, R.C.; Chapman, D.; Cheshire, D.R.; Dixon, J.; Ince, F.; Kinchin, E.C.; Lyons, A.J.; Davis, A.M.; Hallam, C.; Harper, S.T.; Unitt, J.F.; Dougall, I.G.; Jackson, D.M.; McKechnie, K.; Young, A.; Simpson, W.T.; Dual D2-receptor and beta2-adrenoceptor agonists for the treatment of airway diseases. 1. Discovery and biological evaluation of some 7-(2-aminoethyl)-4-hydroxybenzothiazol-2(3H)-one analogues. J Med Chem 1998, 41, 25, 4915. |
| 【2】 Bonnert, R.V.; Brown, R.C.; Cage, P.A.; et al.; Dual D2-receptor and beta2-adrenoceptor agonists for the treatment of airways diseases. 15th European Federation for Medicinal Chemistry International Symposium on Medicinal Chemistry (Sept 6 1998, Edinburgh) 1998, Abst P.275. |
| 【3】 Bonnert, R.V.; Brown, R.C.; Chapman, D.; et al.; Dual D2-receptor and beta2-adrenoceptor agonists for the treatment of airways diseases. 15th European Federation for Medicinal Chemistry International Symposium on Medicinal Chemistry (Sept 6 1998, Edinburgh) 1998, Abst P.276. |
| 【4】 Bonnert, R.V.; Brown, R.C.; Cheshire, D.R.; Ince, F. (AstraZeneca AB); 7-(2-Aminoethyl)-benzothiazolones. EP 0649418; JP 1996503923; US 5648370; WO 9324473 . |
| 【5】 Castañer, J.; Graul, A.; Viozan. Drugs Fut 2000, 25, 2, 165. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| 10180 | Thiourea | 62-56-6 | CH4N2S | 详情 | 详情 | |
| 23660 | 2-Bromoacetic acid | 79-08-3 | C2H3BrO2 | 详情 | 详情 | |
| (I) | 12573 | 3-Bromo-1-propanol; 3-Bromopropanol | 627-18-9 | C3H7BrO | 详情 | 详情 |
| (II) | 25939 | 3-sulfanyl-1-propanol | 19721-22-3 | C3H8OS | 详情 | 详情 |
| (III) | 18456 | 2-phenylacetaldehyde | 122-78-1 | C8H8O | 详情 | 详情 |
| (IV) | 25940 | 2-benzyl-1,3-oxathiane | C11H14OS | 详情 | 详情 | |
| (V) | 25941 | 3-(phenethyloxy)propylhydrosulfide; 3-(phenethyloxy)-1-propanethiol | C11H16OS | 详情 | 详情 | |
| (VI) | 25942 | 2-[[3-(phenethyloxy)propyl]sulfanyl]acetic acid | C13H18O3S | 详情 | 详情 | |
| (VII) | 25943 | 2-[[3-(phenethyloxy)propyl]sulfonyl]acetic acid | C13H18O5S | 详情 | 详情 | |
| (VIII) | 25944 | 7-(2-aminoethyl)-4-hydroxy-1,3-benzothiazol-2(3H)-one | C9H10N2O2S | 详情 | 详情 | |
| (IX) | 25945 | N-[2-(4-hydroxy-2-oxo-2,3-dihydro-1,3-benzothiazol-7-yl)ethyl]-2-[[3-(phenethyloxy)propyl]sulfonyl]acetamide | C22H26N2O6S2 | 详情 | 详情 |
合成路线2
该中间体在本合成路线中的序号：(VIII)The target compound can also be obtained by reductocondensation of benzothiazolone (VIII) with aldehyde (XIII) by means of sodium cynonoborohydride.
| 【1】 Bonnert, R.V.; Brown, R.C.; Cage, P.A.; et al.; Dual D2-receptor and beta2-adrenoceptor agonists for the treatment of airways diseases. 15th European Federation for Medicinal Chemistry International Symposium on Medicinal Chemistry (Sept 6 1998, Edinburgh) 1998, Abst P.275. |
| 【2】 Bonnert, R.V.; Brown, R.C.; Chapman, D.; et al.; Dual D2-receptor and beta2-adrenoceptor agonists for the treatment of airways diseases. 15th European Federation for Medicinal Chemistry International Symposium on Medicinal Chemistry (Sept 6 1998, Edinburgh) 1998, Abst P.276. |
合成路线3
该中间体在本合成路线中的序号：(X)Condensation of 2-(4-methylphenyl)ethanol (I) with t-Bu-bromoacetate (II) in toluene in the presence of NaOH and tetrabutylammonium bromide (TBAB) provides ethoxyacetic acid derivative (III), which is converted into acetamide (V) by reaction with oxalyl chloride (IV) in toluene/DMF followed by treatment with NH4OH. Reduction of (V) by reaction with borane-tetrahydrofuran (BH3·THF) in THF yields ethanamine (VI), which is then coupled to chlorosulfonyl derivative (VII) in CH2Cl2 in the presence of TEA to afford compound (VIII). Reduction of the ester group of (VIII) by treatment with diisobutylaluminium hydride (DIBAL) in toluene furnishes aldehyde (IX), which is finally subjected to a reductive amination with benzothiazol derivative (X) by means of NaCNBH3 in MeOH/HOAc.
| 【1】 Bonnert, R.; et al.; The discovery of dual D2-receptor and beta2-adrenoceptor agonists for the treatment of airway diseases. 16th Int Symp Med Chem (Sept 18 2000, Bologna) 2000, Poster PC161. |
| 【2】 Bonnert, R.V.; Brown, R.C.; Cage, P.A.; Ince, F.; Pairaudeau, G. (AstraZeneca plc); Benzothiazolone derivs.. JP 1999512422; US 5846989; WO 9710227 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 45458 | 2-(4-methylphenyl)-1-ethanol | 699-02-5 | C9H12O | 详情 | 详情 |
| (II) | 17430 | 2-Bromoacetic acid tert-butyl ester; tert-butyl 2-bromoacetate; tert-Butyl bromoacetate | 5292-43-3 | C6H11BrO2 | 详情 | 详情 |
| (III) | 45459 | 2-[(4-methylphenethyl)oxy]acetic acid | C11H14O3 | 详情 | 详情 | |
| (IV) | 29841 | Oxalyl chloride; 2-Chloro-2-oxoacetyl chloride | 79-37-8 | C2Cl2O2 | 详情 | 详情 |
| (V) | 45460 | 2-[(4-methylphenethyl)oxy]acetamide | C11H15NO2 | 详情 | 详情 | |
| (VI) | 45461 | 2-[(4-methylphenethyl)oxy]ethylamine; 2-[(4-methylphenethyl)oxy]-1-ethanamine | C11H17NO | 详情 | 详情 | |
| (VII) | 45462 | Methyl 3-(chlorosulfonyl)propanoate; 3-(Chlorosulfonyl)propionic acid methylester | 15441-07-3 | C4H7ClO4S | 详情 | 详情 |
| (VIII) | 45463 | methyl 3-[([2-[(4-methylphenethyl)oxy]ethyl]amino)sulfonyl]propanoate | C15H23NO5S | 详情 | 详情 | |
| (IX) | 45464 | N-[2-[(4-methylphenethyl)oxy]ethyl]-3-oxo-1-propanesulfonamide | C14H21NO4S | 详情 | 详情 | |
| (X) | 25944 | 7-(2-aminoethyl)-4-hydroxy-1,3-benzothiazol-2(3H)-one | C9H10N2O2S | 详情 | 详情 |