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【结 构 式】 
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【分子编号】25916 【品名】(4S)-4-hydroxy-4-methyl-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 【CA登记号】 |
【 分 子 式 】C20H16N2O4 【 分 子 量 】348.35812 【元素组成】C 68.96% H 4.63% N 8.04% O 18.37% |
与该中间体有关的原料药合成路线共 2 条
合成路线1
该中间体在本合成路线中的序号：(I)By esBy esterification of camptothecin (I) with propionic anhydride in pyridine. terification of camptothecin (I) with propionic anhydride in pyridine.
| 【1】 Cao, Z.; et al.; Alkyl esters of camptothecin and 9-nitrocamptothecin: Synthesis, in vitro pharmacokinetics, toxicity, and antitumor activity. J Med Chem 1998, 41, 1, 31. |
| 【2】 Ciovanella, B.C.; Zhisong, C. (The Stehlin Foundation for Cancer Research); Derivs. of camptothecin for use in treating cancer. EP 0879236; WO 9728165 . |
合成路线2
该中间体在本合成路线中的序号：(I)Acylation of the tertiary 20-hydroxy group of camptothecin (I) with N-Boc-valine-N-carboxyanhydride (II) afforded the corresponding ester (III). Subsequent acidic N-Boc group cleavage gave amino ester (IV). This was coupled with N-Boc-histidine (V) to furnish, after treatment with trifluoroacetic acid, the histidyl-valyl camptothecin ester (VI).
| 【1】 Lerchen, H.-G.; et al.; Design and optimization of 20-O-linked camptothecin glyconjugates as anticancer agents. J Med Chem 2001, 44, 24, 4186. |
| 【2】 Baumgarten, J.; Von dem Bruch, K.; Lerchen, H.-G.; Sperzel, M. (Bayer AG); 20(S) Camptothecin glycoconjugates. DE 19801037; DE 19813137; EP 0981542; JP 2001526661; WO 9851703 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 25916 | (4S)-4-hydroxy-4-methyl-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione | C20H16N2O4 | 详情 | 详情 | |
| (II) | 35318 | tert-butyl (4S)-4-isopropyl-2,5-dioxo-1,3-oxazolidine-3-carboxylate | 141468-55-5 | C11H17NO5 | 详情 | 详情 |
| (III) | 52487 | 4-ethyl-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-4-yl 2-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-3-methylbutanoate | C30H33N3O7 | 详情 | 详情 | |
| (IV) | 52488 | 4-ethyl-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-4-yl 2-amino-3-methylbutanoate | C25H25N3O5 | 详情 | 详情 | |
| (V) | 42808 | (2S)-2-[(tert-butoxycarbonyl)amino]-3-(1H-imidazol-5-yl)propionic acid | 17791-52-5 | C11H17N3O4 | 详情 | 详情 |
| (VI) | 52489 | 4-ethyl-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-4-yl 2-{[2-amino-3-(1H-imidazol-5-yl)propanoyl]amino}-3-methylbutanoate | C31H32N6O6 | 详情 | 详情 |
Extended Information