CZ-48, -Drug Synthesis Database

【结构式】

【药物名称】CZ-48

【化学名称】4(S)-Ethyl-4-(propionyloxy)-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-dione
　　　　　　20(S)-(Propionyloxy)camptothecin

【CA登记号】194414-69-2

【分子式】C₂₃H₂₀N₂O₅

【分子量】404.42625

【开发单位】Stehlin Foundation for Cancer Research (Originator)

【药理作用】ONCOLYTIC DRUGS, Camptothecins, DNA Topoisomerase I Inhibitors, DNA-Intercalating Drugs

合成路线1

By esBy esterification of camptothecin (I) with propionic anhydride in pyridine. terification of camptothecin (I) with propionic anhydride in pyridine.

参考文献中间体

【1】 Cao, Z.; et al.; Alkyl esters of camptothecin and 9-nitrocamptothecin: Synthesis, in vitro pharmacokinetics, toxicity, and antitumor activity. J Med Chem 1998, 41, 1, 31.
【2】 Ciovanella, B.C.; Zhisong, C. (The Stehlin Foundation for Cancer Research); Derivs. of camptothecin for use in treating cancer. EP 0879236; WO 9728165 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(A)	20095	propionic anhydride	123-62-6	C₆H₁₀O₃	详情	详情
(I)	25916	(4S)-4-hydroxy-4-methyl-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione		C₂₀H₁₆N₂O₄	详情	详情

Extended Information

Drug NewChemical Entity Original Patent(2)