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【结 构 式】 
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【分子编号】25753 【品名】10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl ethyl ether; 5-ethoxy-10,11-dihydro-5H-dibenzo[a,d]cycloheptene 【CA登记号】 |
【 分 子 式 】C17H18O 【 分 子 量 】238.32932 【元素组成】C 85.67% H 7.61% O 6.71% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(I)Title compound was obtained by alkylation of 5-ethoxy-10,11-dihydrodibenzocycloheptane (I) with N,N-dimethylaminoethyl chloride (II) in the presence of potassium amide in liquid ammonia.
| 【1】 Ting, P.C.; Solomon, D.L.; Friary, R.J.; Villani, F.J.; Piwinski, J.J.; Lee, J.F.; Seidl, V.A.; Jakway, J.P.; Vashi, D.B. (Schering Corp.); Tricyclic derivs., pharmaceutical compsns. containing them. EP 0733035; JP 1997500656; US 5538986; WO 9515939 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 25753 | 10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl ethyl ether; 5-ethoxy-10,11-dihydro-5H-dibenzo[a,d]cycloheptene | C17H18O | 详情 | 详情 | |
| (II) | 11907 | Dimethylaminoethyl chloride; 2-Dimethylaminoethyl chloride; 2-Chloro-N,N-dimethyl-1-ethanamine; N-(2-Chloroethyl)-N,N-dimethylamine | 107-99-3 | C4H10ClN | 详情 | 详情 |
Extended Information