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【结 构 式】 
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【药物名称】SCH-23863 【化学名称】N-[2-(5-Ethoxy-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)ethyl]-N,N-dimethylamine 【CA登记号】 【 分 子 式 】C21H27NO 【 分 子 量 】309.45544 |
【开发单位】Schering-Plough (Originator) 【药理作用】Antiallergy/Antiasthmatic Drugs, Antiarthritic Drugs, ANTIINFECTIVE THERAPY, Asthma Therapy, RESPIRATORY DRUGS, TREATMENT OF MUSCULOSKELETAL & CONNECTIVE TISSUE DISEASES, Treatment of Septic Shock, Cytokine Production Inhibitors |
合成路线1
Title compound was obtained by alkylation of 5-ethoxy-10,11-dihydrodibenzocycloheptane (I) with N,N-dimethylaminoethyl chloride (II) in the presence of potassium amide in liquid ammonia.
| 【1】 Ting, P.C.; Solomon, D.L.; Friary, R.J.; Villani, F.J.; Piwinski, J.J.; Lee, J.F.; Seidl, V.A.; Jakway, J.P.; Vashi, D.B. (Schering Corp.); Tricyclic derivs., pharmaceutical compsns. containing them. EP 0733035; JP 1997500656; US 5538986; WO 9515939 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 25753 | 10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl ethyl ether; 5-ethoxy-10,11-dihydro-5H-dibenzo[a,d]cycloheptene | C17H18O | 详情 | 详情 | |
| (II) | 11907 | Dimethylaminoethyl chloride; 2-Dimethylaminoethyl chloride; 2-Chloro-N,N-dimethyl-1-ethanamine; N-(2-Chloroethyl)-N,N-dimethylamine | 107-99-3 | C4H10ClN | 详情 | 详情 |
Extended Information