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【结 构 式】

【分子编号】26039

【品名】2,4-dimethyl-8-[[2'-(1H-1,2,3,4-tetraazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]pyrido[2,3-d]pyrimidin-7(8H)-one

【CA登记号】

【 分 子 式 】C23H19N7O

【 分 子 量 】409.45044

【元素组成】C 67.47% H 4.68% N 23.95% O 3.91%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(IV)

4) The condensation of 2,4-dimethylpyrido[2,3-d]pyrimidin-7(8H)-one (XX) with 4'-(bromomethyl)biphenyl-2-carbonitrile (XXI) by means of NaH in DMF gives 8-(2'-cyanobiphenyl-4-ylmethyl)-2,4-dimethylpyrido[2,3-d]pyrimidin-7(8H)-one (XIX), which is then cyclized with sodium azide in refluxing xylene to afford metabolite (IV).

1 Ellingboe, J.W.; Collini, M.D.; Quagliato, D.; Chen, J.; Antane, M.; Schmid, J.; Hartupee, D.; White, V.; Park, C.H.; Tanikella, T.; Bagli, J.F.; Metabolites of the angiotensin II antagonist tasosartan: The importance of a second acidic group. J Med Chem 1998, 41, 22, 4251.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(IV) 26039 2,4-dimethyl-8-[[2'-(1H-1,2,3,4-tetraazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]pyrido[2,3-d]pyrimidin-7(8H)-one C23H19N7O 详情 详情
(XX) 26037 2,4-dimethylpyrido[2,3-d]pyrimidin-7(8H)-one C9H9N3O 详情 详情
(XXI) 15332 4'-(bromomethyl)[1,1'-biphenyl]-2-carbonitrile; 4'-bromomethyl-2-cyanobiphenyl 114772-54-2 C14H10BrN 详情 详情
(XXII) 26038 4'-[[2,4-dimethyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl]methyl][1,1'-biphenyl]-2-carbonitrile C23H18N4O 详情 详情
Extended Information