4'-[[2,4-dimethyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl]methyl][1,1'-biphenyl]-2-carbonitrile -Drug Synthesis Database

【结构式】

【分子编号】26038

【品名】4'-[[2,4-dimethyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl]methyl][1,1'-biphenyl]-2-carbonitrile

【CA登记号】

【分子式】C₂₃H₁₈N₄O

【分子量】366.42228

【元素组成】C 75.39% H 4.95% N 15.29% O 4.37%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(XXII)

4) The condensation of 2,4-dimethylpyrido[2,3-d]pyrimidin-7(8H)-one (XX) with 4'-(bromomethyl)biphenyl-2-carbonitrile (XXI) by means of NaH in DMF gives 8-(2'-cyanobiphenyl-4-ylmethyl)-2,4-dimethylpyrido[2,3-d]pyrimidin-7(8H)-one (XIX), which is then cyclized with sodium azide in refluxing xylene to afford metabolite (IV).

参考文献中间体

合成目标

【1】 Ellingboe, J.W.; Collini, M.D.; Quagliato, D.; Chen, J.; Antane, M.; Schmid, J.; Hartupee, D.; White, V.; Park, C.H.; Tanikella, T.; Bagli, J.F.; Metabolites of the angiotensin II antagonist tasosartan: The importance of a second acidic group. J Med Chem 1998, 41, 22, 4251.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(IV)	26039	2,4-dimethyl-8-[[2'-(1H-1,2,3,4-tetraazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]pyrido[2,3-d]pyrimidin-7(8H)-one		C₂₃H₁₉N₇O	详情	详情
(XX)	26037	2,4-dimethylpyrido[2,3-d]pyrimidin-7(8H)-one		C₉H₉N₃O	详情	详情
(XXI)	15332	4'-(bromomethyl)[1,1'-biphenyl]-2-carbonitrile; 4'-bromomethyl-2-cyanobiphenyl	114772-54-2	C₁₄H₁₀BrN	详情	详情
(XXII)	26038	4'-[[2,4-dimethyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl]methyl][1,1'-biphenyl]-2-carbonitrile		C₂₃H₁₈N₄O	详情	详情

Extended Information