4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride -Drug Synthesis Database

【结构式】

【分子编号】25592

【品名】4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride

【CA登记号】1191-50-0

【分子式】C₁₁H₁₄ClN

【分子量】195.6916

【元素组成】C 67.51% H 7.21% Cl 18.12% N 7.16%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(IV)

Tetrahydrobenzindole (I) was alkylated with 1,4-dibromobutane (II) in the presence of NaH to afford the bromobutyl derivative (III). This was then condensed with 4-phenyltetrahydropyridine (IV) to yield the title compound.

参考文献中间体

合成目标

【1】 Kikuchi, C.; et al.; Tetrahydrobenzindoles: Selective antagonists of the 5-HT7 receptor. J Med Chem 1999, 42, 4, 533.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	25590	2a,3,4,5-tetrahydrobenzo[cd]indol-2(1H)-one	96933-21-0	C₁₁H₁₁NO	详情	详情
(II)	11883	1,4-Dibromobutane; 1,4-Butylene bromide	110-52-1	C₄H₈Br₂	详情	详情
(III)	25591	2a-(4-bromobutyl)-2a,3,4,5-tetrahydrobenzo[cd]indol-2(1H)-one		C₁₅H₁₈BrNO	详情	详情
(IV)	25592	4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride	1191-50-0	C₁₁H₁₄ClN	详情	详情

Extended Information