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【结 构 式】 
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【药物名称】DR-4004 【化学名称】2a-[4-(4-Phenyl-1,2,3,6-tetrahydropyridin-1-yl)butyl]-1,2,2a,3,4,5-hexahydrobenz[cd]indol-2-one 【CA登记号】201608-41-5 【 分 子 式 】C26H30N2O 【 分 子 量 】386.5418 |
【开发单位】Meiji Seika (Originator) 【药理作用】Antidepressants, Anxiolytics, Mood Disorders, Treatment of, PSYCHOPHARMACOLOGIC DRUGS, Sedative/Hypnotics, Sleep Disorders, Treatment of, 5-HT7 Antagonists |
合成路线1
Tetrahydrobenzindole (I) was alkylated with 1,4-dibromobutane (II) in the presence of NaH to afford the bromobutyl derivative (III). This was then condensed with 4-phenyltetrahydropyridine (IV) to yield the title compound.
| 【1】 Kikuchi, C.; et al.; Tetrahydrobenzindoles: Selective antagonists of the 5-HT7 receptor. J Med Chem 1999, 42, 4, 533. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 25590 | 2a,3,4,5-tetrahydrobenzo[cd]indol-2(1H)-one | 96933-21-0 | C11H11NO | 详情 | 详情 |
| (II) | 11883 | 1,4-Dibromobutane; 1,4-Butylene bromide | 110-52-1 | C4H8Br2 | 详情 | 详情 |
| (III) | 25591 | 2a-(4-bromobutyl)-2a,3,4,5-tetrahydrobenzo[cd]indol-2(1H)-one | C15H18BrNO | 详情 | 详情 | |
| (IV) | 25592 | 4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride | 1191-50-0 | C11H14ClN | 详情 | 详情 |
Extended Information