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【结 构 式】 
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【分子编号】25548 【品名】(1R,3aS,5aR,5bR,9S,11aR)-3a-(hydroxymethyl)-1-isopropenyl-5a,5b,8,8,11a-pentamethylicosahydro-1H-cyclopenta[a]chrysen-9-ol 【CA登记号】473-98-3 |
【 分 子 式 】C30H50O2 【 分 子 量 】442.7258 【元素组成】C 81.39% H 11.38% O 7.23% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(I)The target diester was obtained by condensation of betulin (I) with an excess of 3,3-dimethyl glutaric anhydride (II) in the presence of 4-(dimethylamino)pyridine in pyridine at 95 C.
| 【1】 Sun, I.-C.; Wang, H.-K.; Kashiwada, Y.; Shen, J.-K.; Cosentino, L.M.; Chen, C.-H.; Yang, L.-M.; Lee, K.-H.; Anti-AIDS agents. 34. Synthesis and structure-activity relationships of betulin derivatives as anti-HIV agents. J Med Chem 1998, 41, 23, 4648. |
| 【2】 Sun, I.C.; Shen, J.K.; Wang, H.K.; Cosentino, L.M.; Lee, K.H.; Anti-AIDS agents. 32. Synthesis and anti-HIV activity of betulin derivatives. Bioorg Med Chem Lett 1998, 8, 10, 1267-1272. |
| 【3】 Sun, I.-C.; Cosentino, L.M.; Lee, K.-H.; Wang, H.-K. (BBI Biotech Research Laboratories, Inc.; University of North Carolina); Acylated betulin and dihydrobetulin derivs., preparation thereof and use thereof. US 6172110 . |
Extended Information