【结 构 式】 |
【分子编号】25422 【品名】methyl 2-cyano-3,3-bis(methylsulfanyl)acrylate 【CA登记号】 |
【 分 子 式 】C7H9NO2S2 【 分 子 量 】203.286 【元素组成】C 41.36% H 4.46% N 6.89% O 15.74% S 31.55% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(II)Title pyrone was prepared by cyclization of p-bromoacetophenone (I) with methyl 2-cyano-3,3-bis(methylthio)propenoate (II) in the presence of KOH in DMF at r.t.
【1】 Ram, V.J.; et al.; Ring transformation reaction: Part II - Reaction specificity of hydrazines towards 6-aryl-4-(methylthio)-2-oxo-2H-pyran-3-carbonitriles and corresponding 3-ethyl carboxylate. Indian J Chem 1993, 32B, 9, 924. |
【2】 Tominaga, Y.; et al.; Synthesis and reactions of 6-aryl- and 6-styryl-3-cyano-4-methylthio-2H-pyran-2-ones. Chem Pharm Bull 1984, 32, 9, 3384. |
【3】 Tominaga, Y.; et al.; Syntheses of 2-pyrone derivatives. Heterocycles 1976, 4, 9, 1493. |
【4】 Parmar, V.S.; et al.; Synthetic and mass spectral fragmentation studies on trisubstituted 2H-pyran-2-ones and comparative EIMS behaviour of biologically active 3,5-disubstituted pyrazoles and isoxazoles. Indian J Chem 1997, 36B, 10, 872. |
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