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【结 构 式】

【分子编号】25422

【品名】methyl 2-cyano-3,3-bis(methylsulfanyl)acrylate

【CA登记号】

【 分 子 式 】C7H9NO2S2

【 分 子 量 】203.286

【元素组成】C 41.36% H 4.46% N 6.89% O 15.74% S 31.55%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(II)

Title pyrone was prepared by cyclization of p-bromoacetophenone (I) with methyl 2-cyano-3,3-bis(methylthio)propenoate (II) in the presence of KOH in DMF at r.t.

1 Ram, V.J.; et al.; Ring transformation reaction: Part II - Reaction specificity of hydrazines towards 6-aryl-4-(methylthio)-2-oxo-2H-pyran-3-carbonitriles and corresponding 3-ethyl carboxylate. Indian J Chem 1993, 32B, 9, 924.
2 Tominaga, Y.; et al.; Synthesis and reactions of 6-aryl- and 6-styryl-3-cyano-4-methylthio-2H-pyran-2-ones. Chem Pharm Bull 1984, 32, 9, 3384.
3 Tominaga, Y.; et al.; Syntheses of 2-pyrone derivatives. Heterocycles 1976, 4, 9, 1493.
4 Parmar, V.S.; et al.; Synthetic and mass spectral fragmentation studies on trisubstituted 2H-pyran-2-ones and comparative EIMS behaviour of biologically active 3,5-disubstituted pyrazoles and isoxazoles. Indian J Chem 1997, 36B, 10, 872.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 25421 1-(4-bromophenyl)-1-ethanone 99-90-1 C8H7BrO 详情 详情
(II) 25422 methyl 2-cyano-3,3-bis(methylsulfanyl)acrylate C7H9NO2S2 详情 详情
Extended Information