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【结 构 式】 
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【药物名称】91/146 【化学名称】6-(4-Bromophenyl)-4-(methylsulfanyl)-2-oxo-2H-pyran-3-carbonitrile 【CA登记号】61380-87-8 【 分 子 式 】C13H8BrNO2S 【 分 子 量 】322.18221 |
【开发单位】Central Drug Research Institute (Originator) 【药理作用】GASTROINTESTINAL DRUGS, Hepatoprotectants, Liver and Biliary Tract Disorders, Treatment of |
合成路线1
Title pyrone was prepared by cyclization of p-bromoacetophenone (I) with methyl 2-cyano-3,3-bis(methylthio)propenoate (II) in the presence of KOH in DMF at r.t.
| 【1】 Ram, V.J.; et al.; Ring transformation reaction: Part II - Reaction specificity of hydrazines towards 6-aryl-4-(methylthio)-2-oxo-2H-pyran-3-carbonitriles and corresponding 3-ethyl carboxylate. Indian J Chem 1993, 32B, 9, 924. |
| 【2】 Tominaga, Y.; et al.; Synthesis and reactions of 6-aryl- and 6-styryl-3-cyano-4-methylthio-2H-pyran-2-ones. Chem Pharm Bull 1984, 32, 9, 3384. |
| 【3】 Tominaga, Y.; et al.; Syntheses of 2-pyrone derivatives. Heterocycles 1976, 4, 9, 1493. |
| 【4】 Parmar, V.S.; et al.; Synthetic and mass spectral fragmentation studies on trisubstituted 2H-pyran-2-ones and comparative EIMS behaviour of biologically active 3,5-disubstituted pyrazoles and isoxazoles. Indian J Chem 1997, 36B, 10, 872. |
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