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【结 构 式】

【分子编号】25129

【品名】2,2-dichloroacetic acid

【CA登记号】79-43-6

【 分 子 式 】C2H2Cl2O2

【 分 子 量 】128.94208

【元素组成】C 18.63% H 1.56% Cl 54.99% O 24.82%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(V)

Grignard reagent (II), prepared from 4-chlorobromobenzene (I) and Mg in refluxing THF, was coupled with 1,10-dibromodecane (III) in the presence of Li2CuCl4 as the catalyst to afford the bromodecyl compound (IV). Then, the dianion of dichloroacetic acid (V), generated in the presence of two equivalents of LDA in cold THF, was alkylated with bromide (IV) to provide the title compound.

1 Meyer, K.; et al.; omega-Substituted alkyl carboxylic acids as antidiabetic and lipid-lowering agents. Eur J Med Chem 1998, 33, 10, 775.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 14733 4-Bromochlorobenzene; 1-bromo-4-chlorobenzene 106-39-8 C6H4BrCl 详情 详情
(II) 25127 bromo(4-chlorophenyl)magnesium 873-77-8 C6H4BrClMg 详情 详情
(III) 18615 1,10-dibromodecane 4101-68-2 C10H20Br2 详情 详情
(IV) 25128 1-(10-bromodecyl)-4-chlorobenzene C16H24BrCl 详情 详情
(V) 25129 2,2-dichloroacetic acid 79-43-6 C2H2Cl2O2 详情 详情
Extended Information