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【结 构 式】 
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【药物名称】BM-17.0744, K-111, LS-30061 【化学名称】12-(4-Chlorophenyl)-2,2-dichlorododecanoic acid 【CA登记号】 【 分 子 式 】C18H25Cl3O2 【 分 子 量 】379.75775 |
【开发单位】Roche 【药理作用】ENDOCRINE DRUGS，ANTIDIABETIC DRUGS |
合成路线1
Grignard reagent (II), prepared from 4-chlorobromobenzene (I) and Mg in refluxing THF, was coupled with 1,10-dibromodecane (III) in the presence of Li2CuCl4 as the catalyst to afford the bromodecyl compound (IV). Then, the dianion of dichloroacetic acid (V), generated in the presence of two equivalents of LDA in cold THF, was alkylated with bromide (IV) to provide the title compound.
| 【1】 Meyer, K.; et al.; omega-Substituted alkyl carboxylic acids as antidiabetic and lipid-lowering agents. Eur J Med Chem 1998, 33, 10, 775. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 14733 | 4-Bromochlorobenzene; 1-bromo-4-chlorobenzene | 106-39-8 | C6H4BrCl | 详情 | 详情 |
| (II) | 25127 | bromo(4-chlorophenyl)magnesium | 873-77-8 | C6H4BrClMg | 详情 | 详情 |
| (III) | 18615 | 1,10-dibromodecane | 4101-68-2 | C10H20Br2 | 详情 | 详情 |
| (IV) | 25128 | 1-(10-bromodecyl)-4-chlorobenzene | C16H24BrCl | 详情 | 详情 | |
| (V) | 25129 | 2,2-dichloroacetic acid | 79-43-6 | C2H2Cl2O2 | 详情 | 详情 |
Extended Information