1-[(3-amino-4-quinolinyl)amino]-2-methyl-2-propanol -Drug Synthesis Database

【结构式】

【分子编号】24965

【品名】1-[(3-amino-4-quinolinyl)amino]-2-methyl-2-propanol

【CA登记号】

【分子式】C₁₃H₁₇N₃O

【分子量】231.2976

【元素组成】C 67.51% H 7.41% N 18.17% O 6.92%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(I)

The cyclization of the diaminoquinoline (I) with ethoxyacetic acid (II) by heating at 120 C gives the imidazoquinoline (III), which is oxidized to the 5-N-oxide (IV) by treatment with peracetic acid. Finally, compound (IV) is aminated by means of ammonium hydroxide and p-toluenesulfonyl chloride in dichloromethane.

参考文献中间体

合成目标

【1】 Graul, A.; Castañer, J.; S-28463. Drugs Fut 1999, 24, 6, 622.
【2】 Nikolaides, N.; Lindstrom, K.J. (3M Pharmaceuticals); Process for preparing quinolone amines. WO 9417043 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	24965	1-[(3-amino-4-quinolinyl)amino]-2-methyl-2-propanol		C₁₃H₁₇N₃O	详情	详情
(II)	24966	2-ethoxyacetic acid	627-03-2	C₄H₈O₃	详情	详情
(III)	24967	1-[2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]-2-methyl-2-propanol		C₁₇H₂₁N₃O₂	详情	详情
(IV)	24968	2-(ethoxymethyl)-1-(2-hydroxy-2-methylpropyl)-1H-imidazo[4,5-c]quinolin-5-ium-5-olate		C₁₇H₂₁N₃O₃	详情	详情

Extended Information