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【结 构 式】

【分子编号】24890

【品名】ethyl 2-cyano-2-(4-cyano-1-methyl-4-piperidinyl)acetate

【CA登记号】

【 分 子 式 】C12H17N3O2

【 分 子 量 】235.286

【元素组成】C 61.26% H 7.28% N 17.86% O 13.6%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(IV)

The condensation of 1-methyl-4-piperidone (I) with ethyl cyanoacetate (II) in refluxing acetic acid gives ethyl (1-methyl-4-piperidylidene)cyanoacetate (III), which by reaction with KCN in ethanol is converted to ethyl (1-methyl-4-cyano-4-piperidyl)cyanoacetate (IV). The decarboxylative hydrolysis of (IV) with refluxing aqueous HCl affords (1-methyl-4-carboxy-4-piperidyl)acetic acid (V), which is esterified with ethanol - HCl to its diethyl ester (VI). Finally, this compound is treated with ethylamine at 200 C.

1 Bruschweiler, C.; Schereier, E.; Sues, R.; Winkler, H.; Improvements in or relating to Spiropiperidyl-Succinimide Derivatives. CH 411895; CH 449628; GB 1041015 .
2 Ghose, K.; RS-86. Drugs Fut 1986, 11, 4, 276.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 10919 1-Methyl-4-piperidone; 1-Methyltetrahydro-4(1H)-pyridinone; N-Methyl-4-piperidone;1-methylpiperidin-4-one 1445-73-4 C6H11NO 详情 详情
(II) 11877 Cyanoacetic acid ethyl ester; Ethyl 2-cyanoacetate; Ethyl cyanoacetate; Ethyl isocyanacetate 105-56-6 C5H7NO2 详情 详情
(III) 24889 ethyl 2-cyano-2-(1-methyl-4-piperidinylidene)acetate C11H16N2O2 详情 详情
(IV) 24890 ethyl 2-cyano-2-(4-cyano-1-methyl-4-piperidinyl)acetate C12H17N3O2 详情 详情
(V) 24891 4-(carboxymethyl)-1-methyl-4-piperidinecarboxylic acid C9H15NO4 详情 详情
(VI) 24892 ethyl 4-(2-ethoxy-2-oxoethyl)-1-methyl-4-piperidinecarboxylate C13H23NO4 详情 详情
Extended Information