4-(4-formylphenyl)-1-piperazinecarbaldehyde -Drug Synthesis Database

【结构式】

【分子编号】24760

【品名】4-(4-formylphenyl)-1-piperazinecarbaldehyde

【CA登记号】

【分子式】C₁₂H₁₄N₂O₂

【分子量】218.25544

【元素组成】C 66.04% H 6.47% N 12.84% O 14.66%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(II)

The reaction of 1-phenylpiperazine (I) with DMF and POCl3 in dichloroethane gives 4-(4-formylpiperazin-1-yl)benzaldehyde (II), which is condensed with indolin-2-one (III) by means of piperidine in refluxing ethanol.

参考文献中间体

合成目标

【1】 Sun, L.; et al.; Synthesis and biological evaluations of 3-substituted indolin-2-ones: A novel class of tyrosine kinase inhibitors that exhibit selectivity toward particular receptor tyrosine kinases. J Med Chem 1998, 41, 14, 2588.
【2】 Tang, P.C.; Sun, L.; McMahon, G. (Sugen, Inc.); Indolinone cpds. for the treatment of disease. EP 0769947; JP 2000026412; US 5780496; US 5792783; US 5880141; US 5883113; US 5883116; WO 9640116 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	10756	N-Phenylpiperazine; 1-Phenylpiperazine; Phenyl piperazine	92-54-6	C₁₀H₁₄N₂	详情	详情
(II)	24760	4-(4-formylphenyl)-1-piperazinecarbaldehyde		C₁₂H₁₄N₂O₂	详情	详情
(III)	18699	1,3-dihydro-2H-indol-2-one	59-48-3	C₈H₇NO	详情	详情

Extended Information